It should also be noted if you use Draco or Meshopt, in addition to loading the models into the scene with scripts, you also need to add the WASM scripts / any changes to model loading yourself.
Example from @yaustar loading a GLB with Draco: https://playcanvas.com/project/730372/overview/loading-draco-compressed-glbs
MeshOpt support is a bit more experimental, if you need a place to start, I have a project showing meshopt compression: https://playcanvas.com/project/779762/overview/load-glb-model-with-meshopt
For ease of use, I’d recommend sticking with FBX since models are easy to tweak in the editor. If you’re looking for faster loading and you’re okay with messing with scripts, load GLBs with scripts. With that you can then use Draco to compress those. If your models require shape keys / morphs, then as a last resort I would go to MeshOpt.