Yes you can, Im doing it currently
Add a SCREEN component and disable the “screen space” so it’s rendered on the 3D space. Place it on front of the main camera, or inside of the camera so it’s visible regardless of where the camera has moved.
Load the 3D model inside of the screen component - you’ll have to scale up x100 since the screen component uses a different scale. Remove “world” layer from the entity and set it to “UI”. Also make sure the camera has the “UI” layer on it.
Now you can make the 3D element interactive doing raycasts, OR what I do, place a transparent button on top of it and use it for the trigger, and play the 3D animation (eg, moving the button) if you have these